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Did you know that your Thyroid Health and MTHFR are interconnected?

On the one hand, MTHFR needs T4 to function; on the other hand, the Thyroid gland needs Methylfolate to make T4.

Were you aware that an estimated 20 million Americans have some form of thyroid disease? Up to 60 percent of those with thyroid disease are unaware of their condition. More than 12 percent of the U.S. population will develop a thyroid condition during their lifetime.

If the thyroid gland functions slowly, you have a sluggish, slow MTHFR enzyme, even if you don’t have an MTHFR variant.

What is the mechanism, the connection between MTHFR and Thyroid Health?

The thyroid gland produces a hormone: T4, named thyroxine.

Thyroxine is needed to convert Vitamin B2 (Riboflavin) into its active form: FAD (Flavin Adenine Dinucleotide). This conversion is necessary.
The MTHFR enzyme must have enough supply of Active Vitamin B2 (FAD) to function. Therefore, the MTHFR enzyme slows down if FAD levels are low due to low thyroxine levels.
When MTHFR is slowing down, a lower amount of Methylfolate (active folate) is available. As a result, it impairs the body’s abilities to heal, detox and reduces the synthesis of SAMe.
SAMe is essential for neurotransmitters balance, estrogen metabolism, and histamine metabolism, AND Thyroid hormone synthesis!

Where do we find Riboflavin (B2)?

Dietary sources of vitamin B2 include Broccoli, Asparagus, Brussel sprouts, salmon, eggs, almonds, and milk.

Other necessary nutrients for the Thyroid

Magnesium, Iodine, Selenium, Zinc, and Tyrosine. Tyrosine is an amino acid (a building block for proteins) necessary for optimal thyroid function.

FYI: A paleo-type diet (often used as a therapeutic diet for a wide range of health conditions) may harm your Thyroid as it will decrease the intake of riboflavin since most processed foods and grains are avoided (sources of B2)

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If you have a slow thyroid, check your MTHFR enzyme activity and folate levels.
If you have an MTHFR mutation, you should also check your thyroid function.

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Dr. Jean-Marc