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Epstein-Barr Virus reactivation likely the cause of long COVID symptoms?

reviewed by Dr. Jean-Marc Sobczyk ND, MD (France)

Credit: Jeffrey E. Gold, Ramazan A. Okyay, Warren E. Licht, and David J. Hurley

A recently published study suggests a possible link between EBV (Epstein Barr Virus reactivation) and Long Haul COVID symptoms.

This is the first time “evidence linking EBV reactivation to long COVID, as well as an analysis of long COVID prevalence, is outlined in a new long COVID study published in the journal Pathogens.”

“Epstein-Barr virus (EBV) reactivation could be resulting from the inflammatory response to coronavirus infection may be the cause of previously unexplained long COVID symptoms — such as fatigue, brain fog, and rashes — that occur in approximately 30% of patients after recovery from initial COVID-19 infection.”

“The researchers then found, in a subset of 68 COVID-19 patients randomly selected from those surveyed, that 66.7% of long COVID subjects versus 10% of controls were positive for EBV reactivation based on positive EBV early antigen-diffuse (EA-D) IgG or EBV viral capsid antigen (VCA) IgM titers. The difference was significant (p < 0.001, Fisher’s exact test).”

What does it mean? 

It means that 2/3 of the individuals diagnosed with Long Haul COVID were also positive for EBV reactivation based on the EBV early antigen testing or EBV IgM testing (usually seen in recent infection with EBV)

How does it help in treating Long COVID? 

This article also suggested that Antiviral drugs such as Ganciclovir could be considered for these positive individuals. 

Alternatively, natural antivirals such as Lauricidin (Monolaurin), Olive Leaf extract could also be considered. 

Before considering starting any of these supplements or drugs, you should always consult with your doctor, GP, PCP. 

The information provided in this article is for educational purposes only and does not constitute in any way a treatment plan.  

Reference to the full article can be found below.

  • Gold, J.E., et al. (2021) Investigation of Long COVID Prevalence and Its Relationship to Epstein-Barr Virus Reactivation. Pathogens. doi.org/10.3390/pathogens10060763.